Opportunity Overview
This project will develop a new, integrative, in-cell methodology exploiting the atomic detail of solution Nuclear Magnetic Resonance (NMR) spectroscopy, to tackle the challenges which currently limit antimicrobial development.
Supramolecular Self-associating Amphiphiles (SSAs) are a new class of = 100 surface active antimicrobial agents and antibiotic/biocide efficacy enhancers invented by JH.
Project aim: To develop a suite of novel high-throughput methods using a bioreactor coupled to an NMR spectrometer, that will enable us to derive the mechanism of action for this technological innovation on the atomic level.
These studies will be validated through the use of complimentary nanodisc studies (references 3 and 4) and microbiological techniques against multidrug resistant ESKAPE pathogens (CH).
This project will develop a new, integrative, in-cell methodology exploiting the atomic detail of solution Nuclear Magnetic Resonance (NMR) spectroscopy, to tackle the challenges which currently limit antimicrobial development.
Supramolecular Self-associating Amphiphiles (SSAs) are a new class of = 100 surface active antimicrobial agents and antibiotic/biocide efficacy enhancers invented by JH.
Project aim: To develop a suite of novel high-throughput methods using a bioreactor coupled to an NMR spectrometer, that will enable us to derive the mechanism of action for this technological innovation on the atomic level.
These studies will be validated through the use of complimentary nanodisc studies (references 3 and 4) and microbiological techniques against multidrug resistant ESKAPE pathogens (CH).
Objectives:
1. Optimise NMR methods to monitor SSA internalisation.
2. Detection of molecular structural alterations upon interaction with bacteria.
3. Monitoring metabolic changes of the bacteria in the presence of antimicrobial agents.
4. Determination of resistance mechanisms at the metabolic level.
5. Development of next-generation SSAs with enhanced...
Supramolecular Self-associating Amphiphiles (SSAs) are a new class of = 100 surface active antimicrobial agents and antibiotic/biocide efficacy enhancers invented by JH.
Project aim: To develop a suite of novel high-throughput methods using a bioreactor coupled to an NMR spectrometer, that will enable us to derive the mechanism of action for this technological innovation on the atomic level.
These studies will be validated through the use of complimentary nanodisc studies (references 3 and 4) and microbiological techniques against multidrug resistant ESKAPE pathogens (CH).
This project will develop a new, integrative, in-cell methodology exploiting the atomic detail of solution Nuclear Magnetic Resonance (NMR) spectroscopy, to tackle the challenges which currently limit antimicrobial development.
Supramolecular Self-associating Amphiphiles (SSAs) are a new class of = 100 surface active antimicrobial agents and antibiotic/biocide efficacy enhancers invented by JH.
Project aim: To develop a suite of novel high-throughput methods using a bioreactor coupled to an NMR spectrometer, that will enable us to derive the mechanism of action for this technological innovation on the atomic level.
These studies will be validated through the use of complimentary nanodisc studies (references 3 and 4) and microbiological techniques against multidrug resistant ESKAPE pathogens (CH).
Objectives:
1. Optimise NMR methods to monitor SSA internalisation.
2. Detection of molecular structural alterations upon interaction with bacteria.
3. Monitoring metabolic changes of the bacteria in the presence of antimicrobial agents.
4. Determination of resistance mechanisms at the metabolic level.
5. Development of next-generation SSAs with enhanced...
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Start FreeSolicitation Details
| Issuing agency | BBSRC |
|---|---|
| Country | United Kingdom |
| Category | Research Development |
| Published | September 30, 2022 |
| Procurement stage | Active solicitation |
| Response due | September 29, 2026 |
| Status | Open — accepting responses |
| Official source | View original notice |
| Last verified | September 20, 2026 |
Source: UK Research and Innovation (UKRI) — Open Government Licence v3.0.
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