Single Source: Post-Stroke Vascular Contributions to Cognitive Impairment and Dementia (VCID) in the United States (U19 - Clinical Trial Not Allowed)

The National Institute of Neurological Disorders and Stroke, with the National Institute on Aging, intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the specific subsets of stroke events that cause cognitive impairment and dementia in post-stroke populations in the United States. With one in three people having a clinical stroke during their lifetime and dementia occurring in an estimated 30% of post-stroke patients, the public health impact of post-stroke cognitive impairment is high. Additional research to understand what clinical factors may causally synergize with stroke to result in cognitive impairment and dementia outcomes is needed.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U19 activity code. Investigators with expertise and insights into this area and awards made under RFA-NS-19-012 are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in stroke, cognitive impairment and dementia, genetics, neuroimaging and other biomarkers, biostatistics, and longitudinal observational studies will be encouraged.