Opportunity Overview
This is a continuous, open announcement with no deadline unless specifically noted.
1. Strategic Opportunity:
The Capability Program Executive for Chemical, Biological, Radiological, and Nuclear Defense (CPE CBRND) invites interested parties to participate in the HEALER portfolio, a next-generation host directed medical countermeasure initiative.
HEALER seeks to develop a diverse portfolio of threat agnostic, host-directed therapeutics that enhance the body’s ability to withstand, mitigate, and recover from the complex physiological impacts of CBRN threats. Because the underlying pathophysiology of injury following CBRN exposure and civilian critical care challenges are often governed by convergent host response mechanisms, this program creates a viable commercial opportunity that exceeds the traditional CBRN mission space. This initiative represents a significant opportunity for industry collaborators by focusing on dual-use therapeutics. This alignment of national security priorities with commercial market incentives offers a path to sustainable product development.
2. Program Vision: Building Threat-Agnostic Host Resilience
The goal of the HEALER portfolio is to create a new generation of therapeutics enabling the 'Host' to recover from physiological impacts and maintain operational effectiveness even under duress. The program focuses on delivering medical countermeasures that provide layered physiological protection to the Warfighter by targeting one or more of the following critical host systems:
Neurological Protection
Respiratory Stabilization
Immune Modulation
Hematologic & Vascular Function
Cellular Stress & Repair Pathways
This integrated approach will ensure the development of a diverse and robust portfolio of threat-agnostic capabilities, empowering the host through enhanced resilience.
3. Call for Collaborators: Who Should Apply?
This announcement serves as an invitation to the full spectrum of drug development organizations.
A....
1. Strategic Opportunity:
The Capability Program Executive for Chemical, Biological, Radiological, and Nuclear Defense (CPE CBRND) invites interested parties to participate in the HEALER portfolio, a next-generation host directed medical countermeasure initiative.
HEALER seeks to develop a diverse portfolio of threat agnostic, host-directed therapeutics that enhance the body’s ability to withstand, mitigate, and recover from the complex physiological impacts of CBRN threats. Because the underlying pathophysiology of injury following CBRN exposure and civilian critical care challenges are often governed by convergent host response mechanisms, this program creates a viable commercial opportunity that exceeds the traditional CBRN mission space. This initiative represents a significant opportunity for industry collaborators by focusing on dual-use therapeutics. This alignment of national security priorities with commercial market incentives offers a path to sustainable product development.
2. Program Vision: Building Threat-Agnostic Host Resilience
The goal of the HEALER portfolio is to create a new generation of therapeutics enabling the 'Host' to recover from physiological impacts and maintain operational effectiveness even under duress. The program focuses on delivering medical countermeasures that provide layered physiological protection to the Warfighter by targeting one or more of the following critical host systems:
Neurological Protection
Respiratory Stabilization
Immune Modulation
Hematologic & Vascular Function
Cellular Stress & Repair Pathways
This integrated approach will ensure the development of a diverse and robust portfolio of threat-agnostic capabilities, empowering the host through enhanced resilience.
3. Call for Collaborators: Who Should Apply?
This announcement serves as an invitation to the full spectrum of drug development organizations.
A....
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Start FreeSolicitation Details
| Issuing agency | W6Qk Acc-Apg |
|---|---|
| Country | United States |
| Category | Scientific Research |
| NAICS | 541714 |
| PSC | AC13 |
| Published | May 06, 2026 |
| Procurement stage | Request for Proposal (RFP) |
| Response due | May 01, 2036 |
| Status | Open — accepting responses |
| Official source | View original notice |
| Last verified | August 10, 2026 |
Source: U.S. Government (SAM.gov) — public domain. GlobalGov is not affiliated with or endorsed by the United States Government.
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