National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Innovative Concept Phase I Award Program

THIS EDIT IS TO POST AMENDMENT #3. AMENDMENT #3 IS TO provide key questions and answers received in writing by email. Offerors are required to submit a signed copy of the SF30 Amendment (page 1 only) with their Business Proposal submission. The deadline for receipt of proposals remains unchanged at 5:00pm, September 21, 2026. All other terms and conditions of the solicitation remain unchanged. PLEASE SEE ATTACHED AMENDMENT #3 PDF. _______________________________________________________________________________________________________ THIS EDIT IS TO POST AMENDMENT #2. AMENDMENT #2 IS TO remove the Data Management Sharing Plan requirement and all references under Sections 5.9 Management and Sharing of Research Data, 6.1 Evaluation Process, Evaluation of Data Management and Sharing Plan, 8.5 Technical Proposal Content (I) Scientific Data Sharing. The deadline for receipt of proposals remains unchanged at 5:00pm, September 21, 2026. All other terms and conditions of the solicitation remain unchanged. PLEASE SEE ATTACHED AMENDMENT #2 PDF. ________________________________________________________________________________________________________ ORIGINAL SOLICITATION DESCRIPTION: The National Cancer Institute (NCI) invites small business concerns to submit research proposals under this Phase I Small Business Innovation Research (SBIR) contract solicitation. Firms with the capability to conduct research and development (R&D) in the health-related topic areas referred to below and described more fully in Section 11.0, and to commercialize the results of that R&D, are encouraged to participate. The topic areas that are being sought under this solicitation are: Topic 1: Development of therapeutic or preventative technologies for treatment or prevention of Pediatric Cancers and/or Rare Cancers. For this solicitation rare cancers with a 5-year survival rate of less than 50% are encouraged. Topic 2: Development of devices, diagnostic technologies, or digital health tools for...