Resilient Systems Office (RSO) Mission Office Innovative Solutions Opening (ISO)

Advanced Research Projects Agency for Health (ARPA-H) · United States government procurement

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March 05, 2029
Response Due
Active
Status

Opportunity Overview

This ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO’s interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care.

Solution summary submissions must be submitted to: https://solutions.arpa-h.gov
Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/
Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/

Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents:   

1) Administrative & National Policy Requirements Document

Updated the instructions and references within the “Organizational Conflicts of Interest (OCI) Affirmations and Disclosure” section.
Updated questions, instructions, and content within the “Research Security Disclosure” section.
Updated the instructions and intellectual property data assertions charts within the “IP” section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the “Non-Commercial” and “Commercial” tables were removed and replaced with the “Background IP and Data Assertions” table.
Eliminated the “Software Component Standards” section.
Updated the Human Subjects Research (HSR) table within the “HSR” section.
Updated the Animal Subjects Research (ASR) table...

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Solicitation Details

Issuing agencyAdvanced Research Projects Agency for Health (ARPA-H)
CountryUnited States
CategoryScientific Research
NAICS541715
PSCAN13
PublishedJanuary 08, 2026
Procurement stageRequest for Proposal (RFP)
Response dueMarch 05, 2029
StatusOpen — accepting responses
Official sourceView original notice
Last verifiedAugust 10, 2026

Source: U.S. Government (SAM.gov) — public domain. GlobalGov is not affiliated with or endorsed by the United States Government.

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